Endocrine Abstracts

Introduction: Cushing’s disease (CD), a hypercorticism caused by an ACTH-secreting pituitary adenoma, was associated with a 5-year survival of only 50%. Although advances in management have significantly reduced mortality, the results of transsphenoidal surgery, the gold standard in the treatment of CD, vary from patient to patient.Objective: The aim of our study is to evaluate the results of transsphenoidal surgery in CD (evolution, complications) ...

Introduction: Hirsutism is defined as excessive pilosity development in women in androgen-dependent areas. It is the main revealing sign of hyperandrogenism. It is a frequent reason for consultation in Endocrinology.Methods: This is a retrospective study of 82 records of patients hospitalized for exploration of hirsutism in the endocrinology department of Farhat Hached Hospital in Sousse, over a period of 20 years from 1997 to 2017.<p class="abstext"...

In ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing Cushing’s syndrome, cortisol secretion is controlled by illegitimate membrane receptors. In the normal adrenal gland, agonists of 5-HT4 receptors have a powerful effect on aldosterone secretion but little effect on cortisol secretion in vitro.The aim of our study is to describe the clinical and hormonal features of patients diagnosed with aberrant serotonin receptor expres...

Giant-cell tumor is a skeletal disorder that occurs secondarily to hyperparathyroidism and is caused by long-term stimulation of parathyroid hormone (PTH) excess. The overactivity and proliferation of osteoclasts stimulated by PTH breaks down bone and leads to replacement of bone matrix and thinning of the cortex. True giant-cell tumor is a rare jaw osteolytic benign tumor belonging to the larger family of giant-cell tumors.We report the case of a 47 yea...

Introduction: Endocrine hypertension is the most common cause of secondary hypertension affecting nearly 3% of the population. Adrenal etiologies play a significant role in these cases. An adrenal incidentaloma is an asymptomatic adrenal tumor, at least one cm in diameter, discovered incidentally during a medical imaging examination. It requires an investigation into its secretory or malignant nature leading to the development of arterial hypertension.Ma...

Introduction: Endogenous Cushing’s disease is a serious and rare endocrine disorder. Medical therapy is mostly used as second-line treatment after failed surgery or recurrence and comprises several pituitary-directed drugs, glucocorticoid receptor blocker and adrenal steroidogenesis inhibitors such as osilodrostat. We here describe a case of a Tunisian patient with uncured cushing’s disease who developed iatrogenic adrenal insufficiency in the setting of Osilodrostat...

Introduction: Verneuil’s disease, also known as Hidradenitis suppurativa, is a chronic inflammatory dermatosis characterized by recurrent episodes. It’s manifested by painful deep inflammatory nodules, comedones, and scarring in areas rich in apocrine glands. Its prevalence is estimated at 1% of the population. It is influenced by factors such as obesity, smoking, and genetics. We report the case of a patient admitted for diabetes in whom Hidradenitis suppurativa was...

Introduction: The most recent declared pandemic is attributed to COVID-19, caused by the novel coronavirus SARS-CoV-2. The angiotensin-converting enzyme 2, the principal receptor for SARS-CoV-2, exhibits expression in various tissues, prominently within gonadal and hypothalamo-hypophyseal domains. Long COVID, characterized by persistent symptoms post-infection, manifests in certain individuals and includes manifestations associated with the genitourinary system, such as sexual...

Introduction: Macroprolactinemia is a polymeric form of prolactin release that leads to clinically paucisymptomatic presentations. It can be isolated or associated with other causes of hyperprolactinemia. We report the case of macroprolactinemia discovered in a patient being treated for an empty sella turcica.Case report: This concerns a 47-year-old patient, monitored since the age of 31 for moderate idiopathic hyperprolactinemia discovered following bil...

Introduction: COVID-19 is a viral infection that can affect various endocrine tissues, including the thyroid. In some patients, symptoms may persist after the infection, defined as Long COVID. Given the similarity of some of these symptoms to those encountered in thyroid disorders, we have decided to assess thyroid function in patients previously infected with SARS-CoV-2.Patients & Methods: This was a prospective study conducted from January to Decem...